The motor system enables us to interact with the environment. The variety of motor activity reaches from “simple” reflexes to “complex” behavior, e.g., goal directed motion towards an object, all relying on an intense interplay of neurons and muscles. To understand the underlying mechanisms, we will investigate how the nervous system processes sensory signals and calculates appropriate motor command signals. When studying motor control, behavioral readouts across species offer the potential to overcome one grand challenge in neuroscience: bridging the gaps between molecular, cellular, and systems levels. CRC1451 brings together neuroscientists investigating genetic factors, cellular, and synaptic as well as systems/neural network processes underlying motor control in animals and humans, in both health and diseases (https://www.crc1451.uni-koeln.de/).