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Faculty of Mathematics and Natural SciencesInstitute of Zoology - AG Roth

Selected Publications

  1. Guichet A, Peri F, Roth S. Stable anterior anchoring of the oocyte nucleus is required to establish dorsoventral polarity of the Drosophila egg. Dev Biol. 2001 Sep 1;237(1):93-106. https://www.ncbi.nlm.nih.gov/pubmed/11518508

  2. Peri F, Technau M, Roth S. Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila. Development. 2002 Jun;129(12):2965-75. https://www.ncbi.nlm.nih.gov/pubmed/12050143

  3. Handel K, Basal A, Fan X, Roth S. Tribolium castaneum twist: gastrulation and mesoderm formation in a short-germ beetle. Dev Genes Evol. 2005 Jan;215(1):13-31. Epub 2004 Nov 30. https://www.ncbi.nlm.nih.gov/pubmed/15645317

  4. van der Zee M, Berns N, Roth S. Distinct functions of the Tribolium zerknüllt genes in serosa specification and dorsal closure. Curr Biol. 2005 Apr 12;15(7):624-36. https://www.ncbi.nlm.nih.gov/pubmed/15823534

  5. Bökel C, Dass S, Wilsch-Bräuninger M, Roth S. Drosophila Cornichon acts as cargo receptor for ER export of the TGFalpha-like growth factor Gurken. Development. 2006 Feb;133(3):459-70. Epub 2006 Jan 5. https://www.ncbi.nlm.nih.gov/pubmed/16396907

  6. van der Zee M, Stockhammer O, von Levetzow C, Nunes da Fonseca R, Roth S. Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16307-12. Epub 2006 Oct 18. https://www.ncbi.nlm.nih.gov/pubmed/17050690

  7. Shravage BV, Altmann G, Technau M, Roth S. The role of Dpp and its inhibitors during eggshell patterning in Drosophila. Development. 2007 Jun;134(12):2261-71. Epub 2007 May 16. http://www.ncbi.nlm.nih.gov/pubmed/17507396

  8. Technau M, Roth S. The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein klaroid have no essential function during oogenesis. Fly (Austin). 2008 Mar 19;2(2). http://www.ncbi.nlm.nih.gov/pubmed/18820478

  9. Nunes da Fonseca R, von Levetzow C, Kalscheuer P, Basal A, van der Zee M, Roth S. Self-regulatory circuits in dorsoventral axis formation of the short-germ beetle Tribolium castaneum. Dev Cell. 2008 Apr;14(4):605-15. http://www.ncbi.nlm.nih.gov/pubmed/18410735

  10. Tribolium Genome Sequencing Consortium. The genome of the model beetle and pest Tribolium castaneum. Nature. 2008 Apr 24;452(7190):949-55. http://www.ncbi.nlm.nih.gov/pubmed/18362917

  11. Van der Zee M, da Fonseca RN, Roth S. TGFbeta signaling in Tribolium: vertebrate-like components in a beetle. Dev Genes Evol. 2008 Apr;218(3-4):203-13. http://www.ncbi.nlm.nih.gov/pubmed/18392881

  12. Roth S, Lynch JA. Symmetry breaking during Drosophila oogenesis. Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a001891. http://www.ncbi.nlm.nih.gov/pubmed/20066085

  13. Fonseca RN, Lynch JA, Roth S. Evolution of axis formation: mRNA localization, regulatory circuits and posterior specification in non-model arthropods. Curr Opin Genet Dev. 2009 Aug;19(4):404-11. Epub 2009 Jun 1. http://www.ncbi.nlm.nih.gov/pubmed/19493672

  14. Panfilio KA, Roth S. Epithelial reorganization events during late extraembryonic development in a hemimetabolous insect. Dev Biol. 2010 Apr 1;340(1):100-15. Epub 2010 Jan 4. PMID: 20045678. http://www.ncbi.nlm.nih.gov/pubmed/20045678

  15. Lynch JA, Peel AD, Drechsler A, Averof M, Roth S. EGF signaling and the origin of axial polarity among the insects. Curr Biol. 2010 Jun 8;20(11):1042-7. Epub 2010 May 13.PMID: 20471269. http://www.ncbi.nlm.nih.gov/pubmed/20471269

  16. Nunes da Fonseca R, van der Zee M, Roth S. Evolution of extracellular Dpp modulators in insects: The roles of tolloid and twisted-gastrulation in dorsoventral patterning of the Tribolium embryo. Dev Biol. 2010 May 26. PMID: 20510683. http://www.ncbi.nlm.nih.gov/pubmed/20510683

  17. Lynch JA, Roth S. The evolution of dorsal-ventral patterning mechanisms in insects. Genes Dev. 2011 Jan 15;25(2):107-18. PMID: 21245164. http://www.ncbi.nlm.nih.gov/pubmed/21245164

  18. Ewen-Campen B, Shaner N, Panfilio KA, Suzuki Y, Roth S, Extavour CG. The maternal and early embryonic transcriptome of the milkweed bug Oncopeltus fasciatus. BMC Genomics. 2011 Jan 25;12:61. PMID: 21266083 http://www.ncbi.nlm.nih.gov/pubmed/21266083

  19. Lynch JA, Özüak O, Khila K, Abouheif E, Desplan C, and Roth S. The phylogenetic origin of oskar coincided with the origin of maternally provisioned germ plasm and pole cells at the base of the Holometabola. PLoS Genetics, 2011 Apr;7(4) http://www.ncbi.nlm.nih.gov/pubmed?term=21552321

  20. S Roth. Mathematics and biology: a Kantian view on the history of pattern formation theory Development genes and evolution 221 (5-6), 255-279 http://www.ncbi.nlm.nih.gov/pubmed/22086125

  21. M Technau, M Knispel, S Roth. Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila. Development genes and evolution 222 (1), 1-17 http://www.ncbi.nlm.nih.gov/pubmed/22198544

  22. S Roth, KA Panfilio. Making waves for segments Science 336 (6079), 306-307 http://www.ncbi.nlm.nih.gov/pubmed/22517849

  23. S Roth, J Lynch. Does the Bicoid gradient matter? Cell 149 (3), 511-512 http://www.ncbi.nlm.nih.gov/pubmed/22541424

  24. S Roth, J Lynch. Axis Formation: Microtubules Push in the Right Direction. Current Biology 22 (13), R537-R539 http://www.ncbi.nlm.nih.gov/pubmed/22790006

  25. AD Baffet, B Benoit, J Januschke, J Audo, V Gourhand, S Roth, A Guichet. Drosophila tubulin-binding cofactor B is required for microtubule network formation and for cell polarity. Molecular biology of the cell 23(18), 3591-3601 http://www.ncbi.nlm.nih.gov/pubmed/22855530

  26. BM Vreede, JA Lynch, S Roth, É Sucena. Co-option of a coordinate system defined by the EGFr and Dpp pathways in the evolution of a morphological novelty. Evo Devo 4 (7) http://www.ncbi.nlm.nih.gov/pubmed/23448685

  27. V Zeng, B Ewen-Campen, HW Horch, S Roth, T Mito, CG Extavour. Developmental gene discovery in a hemimetabolous insect: de novo assembly and annotation of a transcriptome for the cricket Gryllus bimaculatus.PLoS One. 2013 May 6;8(5) http://www.ncbi.nlm.nih.gov/pubmed/23671567

  28. T Buchta, O Özüak, D Stappert, S Roth, JA Lynch. Patterning the dorsal–ventral axis of the wasp Nasonia vitripennis. Developmental biology 381 (1), 189-202 http://www.ncbi.nlm.nih.gov/pubmed/23735637

  29. KA Panfilio, G Oberhofer, S Roth. High plasticity in epithelial morphogenesis during insect dorsal closure. Biology open 2 (11), 1108-1118 http://www.ncbi.nlm.nih.gov/pubmed/24244847

  30. KA Panfilio, S Roth. Development: Getting into the Groove, or Evolving off the Rails? Current Biology 23 (24), R1101-R1103 http://www.ncbi.nlm.nih.gov/pubmed/24355787

  31. O Özüak, T Buchta, S Roth, JA Lynch. Dorsoventral polarity of the Nasonia embryo primarily relies on a BMP gradient formed without input from Toll. Current Biology 24 (20), 2393-2398 http://www.ncbi.nlm.nih.gov/pubmed/25308075

  32. O Özüak, T Buchta, S Roth, JA Lynch. Ancient and diverged TGF-β signaling components in Nasonia vitripennis. Development genes and evolution 224 (4-6), 223-233 http://www.ncbi.nlm.nih.gov/pubmed/25304164

  33. L Sachs, YT Chen, A Drechsler, JA Lynch, KA Panfilio, M Lässig, J Berg, S Roth. Dynamic BMP signaling polarized by Toll patterns the dorsoventral axis in a hemimetabolous insect. eLife 4, e05502 http://www.ncbi.nlm.nih.gov/pubmed/25962855

  34. AP Moczek, KE Sears, A Stollewerk, PJ Wittkopp, P Diggle, I Dworkin, ...The significance and scope of evolutionary developmental biology: a vision for the 21st century. Evolution & development 17 (3), 198-219 http://www.ncbi.nlm.nih.gov/pubmed/25963198

  35. C Schmitt-Engel, D Schultheis, J Schwirz, N Ströhlein, N Troelenberg, ... The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology. Nature communications 6 http://www.ncbi.nlm.nih.gov/pubmed/26215380

  36. Benton MA, Pechmann M, Frey N, Stappert D, Conrads KH, Chen YT, Stamataki E, Pavlopoulos A, Roth S. Toll Genes Have an Ancestral Role in Axis Elongation. https://www.ncbi.nlm.nih.gov/pubmed/27212406

  37. Misra M, Edmund H, Ennis D, Schlueter MA, Marot JE, Tambasco J, Barlow I, Sigurbjornsdottir S, Mathew R, Vallés AM, Wojciech W, Roth S, Davis I, Leptin M, Gavis ER. A Genome-Wide Screen for Dendritically Localized RNAs Identifies Genes Required for Dendrite Morphogenesis. https://www.ncbi.nlm.nih.gov/pubmed/27260999

  38. Stappert D, Frey N, von Levetzow C, Roth S. Genome-wide identification of Tribolium dorsoventral patterning genes. https://www.ncbi.nlm.nih.gov/pubmed/27287803

  39. Pers D, Buchta T, Özüak O, Wolff S, Pietsch JM, Memon MB, Roth S, Lynch JA. Global analysis of dorsoventral patterning in the wasp Nasonia reveals extensive incorporation of novelty in a regulatory network. https://www.ncbi.nlm.nih.gov/pubmed/27480122

  40. Benton MA, Kenny NJ, Conrads KH, Roth S, Lynch JA. Deep, Staged Transcriptomic Resources for the Novel Coleopteran Models Atrachya menetriesi and Callosobruchus maculatus. https://www.ncbi.nlm.nih.gov/pubmed/27907180

Complete list of publications (search Pubmed for: Roth-S)